Topiramate is used alone or together with other medicines to help treat certain types of seizures (eg, partial seizures, tonic-clonic seizures, or Lennox-Gastaut syndrome). This medicine will not cure epilepsy and will only work to control seizures for as long as you continue to take it. It is also used to help prevent migraine headaches.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

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Given evidence that emotion dysregulation may affect physical health by altering physiological functioning, one mechanism that warrants examination is emotion dysregulation. A quantitative enzyme-linked immunoassay for the detection of 2, 6-dichlorobenzamide (BAM), a degradation product of the herbicide dichlobenil. Tyrosine phosphorylation of c-Cbl occurred within 20 s after stimulation and reached maximum levels within 3-5 min. The findings will also assist HIV services to align with broader public health goals related to increasing ART use and improving quality of life among people living with HIV.

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The likely contribution of this reflex to the control of movement is discussed. Detection of biological threat agents by immunomagnetic microsphere-based solid phase fluorogenic- and electro-chemiluminescence. EBER-1 was detected in nuclei of tumor cells in 8/9 cases of MTL and LMP-1 was found on membrane and in cytoplasm of tumor cells in 7/9 cases of MTL.

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There was no significant difference in the return of fertility of women having used either device. The pediatrician is the primary health care provider to explore and assist with the pubertal transition and menstrual management.

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To facilitate the adoption of UKPDS findings, clear guidelines are needed, providing specific recommendations about subgroups of patients showing a higher risk of complications as well as of inappropriate care. To test the hypothesis that dairy farms certified in the Milk and Dairy Beef Quality Assurance Program (QAP) were more likely to use prudent drug management practices than farms that were not certified. Childhood mortality clearly increased after the Gulf conflict and under UN sanctions in the south/centre of Iraq, but in the autonomous region since the start of the Oil-for-Food Programme childhood mortality has begun to decline.

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In addition, expression of the mRNA that encodes the endogenous agonists and antagonists for CNS melanocortin receptors is regulated by changes in energy balance and body-adiposity signals. More importantly, the actuators show a pronounced increase of conductivity due to the deformation induced by the moisture change, which allows the integration of a moisture-sensitive actuator and a humidity sensor. Neutralizing anti-interleukin (IL)-6 and tumor necrosis factor-alpha antibodies inhibited coculture conditioned medium-induced MMP-1 production by VSMCs and THP-1 cells.

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To analyze this innovative contact mechanism, particle velocity synthesis theory and contact force analysis using Hertz contact model are carried out. Quantum diffusion dynamics in nonlinear systems: a modified kicked-rotor model. Each of PAF, ACTH, or FRK eliminated the cortisol response to OAG plus A23187, whereas that to FRK was unaffected. To our knowledge, this is the first example in which cytoprotection by resveratrol has been demonstrated by EPR spin-trapping competition kinetics to be due to its scavenging of the radicals responsible for the toxicity of a prooxidant. As a result, the present study was undertaken to investigate the kinetics of the efficacy mediated by the IFN-alpha1 transgene following ocular challenge with HSV-1.

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In paleopathology, HLs are used to reconstruct health status of past populations. Second drugs were added if needed (metoprolol and prazosin, respectively). Histopathological changes in malignant melanoblastoma of the choroid after light-coagulation. At 1 nmol, changes in blood pressure and HR were evident at 5 min, and remained for 45 min after injection.

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The large difference in hydration changes by both BamHI and EcoRI could be attributed to these dissimilar secondary structural features, as well as the functional differences of the two endonucleases during site-specific DNA recognition. Decrease of disease activity under ineffective therapy in DMARD-naive patients with early rheumatoid arthritis: role of antibody profiles and carriage of the HLA shared epitope in predicting decrease of disease activity. In neurons in which responses to TP stimulation were inhibited, responses elicited by electrical stimulation of the mesencephalic reticular formation (MRF) were also inhibited. Curvature distribution in all prokaryotes of the first group indicated a substantial fraction of promoters characterized by intrinsic DNA curvature located within or upstream of the promoter region. CRISPR/Cas9 is the latest synthetic endonuclease that has revolutionized basic research by allowing facile genome editing in prokaryotes and eukaryotes.

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Many of the monoclonal antibody preparations showed specificity toward the carbohydrate moiety of the glycopeptides and crossreacted immunologically with various glycoprotein preparations, whereas some were specific to the glycopeptides. Dynamic positron emission tomography (PET) is a powerful tool that provides useful quantitative information on physiological and biochemical processes. The obese patient: an acceptable candidate for outpatient anesthesia. Experiments using a duct with a finite section of tensioned membrane are compared with the propagating modes pertaining to the infinite membrane model.

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Toddler temperament and prenatal exposure to lead and maternal depression. Effect of exogenous melatonin on mood and sleep efficiency in emergency medicine residents working night shifts. The tests provide new diagnostic tools for identifying Neisseria infections. Preleukemic cells were located mainly among four out of 21 fractions tested, consisting mostly of 10 to 14 micrometers size cells. Progressive multifocal leukoencephalopathy (PML) is one of the major risks of natalizumab therapy.

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Oestradiol valerate and 17 beta-oestradiol are virtually dose-equivalent. Predictive control of muscle responses to arm perturbations in cerebellar patients.

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Acanthopagrus schlegelii is a warm temperate demersal fish, which inhabits the sediment substrate or rocky reefs in shallow seas. Measurement of the systolic blood pressures at ankle level by means of a sphygmomanometric method and a Doppler flowmeter allows reliable determination of the presence or absence of haemodynamically significant arterial obstructions. The root surface was not specifically conditioned, and osseous grafts were not used. Herbal supplements are widely used for a variety of indications, and both patients and health care practitioners are often unaware of the anticoagulant and antiplatelet effects that occur as either predictable pharmacologic effects or adverse side effects of herbal medicines. Drug use by mentally handicapped persons in institutions and family-replacing residential facilities

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The data show that mouse bone marrow potentiator activity is a variant of IL-6 and with the potential to enhance megakaryocyte growth. In a double blind study of the effects of low doses of caffeine on aggression, rats were housed four per cage, and aggressive behavior against an intruder was recorded during baseline and following administration of 2.5, 5, 10, and 20 mg/kg caffeine. Oxidative stress and protein glycation are closely related processes that may contribute to the development of complications in diabetes mellitus. Temporal stability of psychophysiological stress profiles: a re-analysis using intraclass correlation coefficients.

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4) Establish a multivariance correlation between the results of the tests according to sex and historical data, looking for one or more regulating factors. The SF-36 and its summary scores are sensitive instruments to detect improvement in QOL in COPD patients after PR. Surgical closure of patent foramen ovale was not performed due to the age of our patient, surgical difficulties, and failure to obtain informed consent.

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Capsaicin receptor TRPV1 and wasabi receptor TRPA1 are expressed in the unmyelinated C fiber nociceptors and activated by various nociceptive stimuli causing pain in our body. The objective of the study was to describe the evolution of growth and skeletal age of a brother and sister of Moroccan descent with a homozygous GHRH-R mutation who presented at an advanced age (16 and 14.9 yr, respectively) and pubertal stage (Tanner stage G4 and B3, respectively) with a height of -5.1 sd score and -7.3 sd score on treatment with a combination of GH and GnRHa for 2.5 and 3 yr followed by GH alone. The effect of this experimental infection was evaluated on circulating leukocytes, nasal-derived mediators, and markers of bronchial inflammation that were obtained by bronchoscopy and lavage. Negative bias and aberrant neural processing of emotional faces are trait-marks of depression but findings in healthy high-risk groups are conflicting. Between T0 and T1, the cephalometric analysis showed a significant decrease of the angulation of the upper central incisors to the SN line and to the palatal plane in GrE together with a significant increase of the lower incisors to the mandibular plane (IMPA).

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GBV-C/HGV is frequently transmitted from mothers to infants in the general population. Forty sound and carious primary and permanent teeth, extracted from children and adolescents of Davangere city, were collected. In view of its variability in pharmacokinetics and the potential for toxicities, serum concentrations often are measured. The distal degree of carotid stenosis was assessed by comparison of the diameter of the distal internal carotid artery obtained intraoperatively with the measurements of the plastic specimens (1 mm vascular wall thickness of distal internal carotid artery was taken into account). Correction of ventricular late potentials with drug and non-drug methods in patients with essential hypertension

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The length of time between addition of the inhibitor of macromolecular synthesis and the onset of apoptosis can be used as an estimation of the effective survival factor concentration. The assumption that women tend to use left-hemispheric, verbal/serial strategies also in spatial tasks was also partly supported. Must indications for cystectomy in bladder carcinoma be reconsidered? Unlike Rev-RRE, the PRE functions independently of splice donor and acceptor sites and can activate cytoplasmic expression of an intronless (so-called prespliced) beta-globin transcript. Specific dyspeptic symptoms are associated with poor response to therapy in patients with gastroesophageal reflux disease.

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Comparison of plasma and saliva concentrations of lamotrigine in healthy volunteers. Fluorescence ratio imaging is a non-invasive technique for studying the formation of microgradients in immobilised bacterial colonies. Vaccine adjuvants, delivery systems and therapeutic vaccination are likely to be the areas of major progress in the future. Bilioenteric fistulas are the abnormal communication between the bile duct system and the gastrointestinal tract that occurs spontaneously and is a rare complication of an untreated gallstone in the majority of cases. Therefore, elucidating the signaling events immediately downstream of DELLA is key to our understanding of how GA controls plant development.

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Classical mutations at the mouse Brachyury (T) locus were discovered because they lead to shortened tails in heterozygous newborns. Eighty-six patients were randomly selected for sequential surgical treatment involving either CEAP/CEE or CEE/CEAP.

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In case of hunger strike legal standards cannot fully replace psychological insight, professional ethics and conscience, however. Descriptive statistics, student t-test, variance and correlation analysis were used for assessment of the data. This case calls attention to the rare condition of congenital nodular calcification of the skin. Transcription factors (TFs) play key roles in controlling gene expression.

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The anatomic basis of the injury to the extensor carpi radialis brevis origin appears to be multifaceted, involving hypovascular zones, eccentric tendon stresses, and a microscopic degenerative response. These comprised 1520 men and women living in London who were randomly selected for the national survey of sexual attitudes and lifestyles and 2414 heterosexual men and women who presented to the GUM clinic with gonorrhoea. Uptake and transport of horseradish peroxidase by cochlear spiral ganglion neurons. They were aligned parallel with the thick actin bundles that appeared as an initial stage of developing myofibrils. We conclude that, in addition to increasing endothelial nitric oxide biosynthesis in placental stem villous arteries, adrenomedullin induces release of an endothelium-derived constricting factor.

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NAIs were related to the histopathologic stage: the highest NAIs were found in 8 cases of classic fibrocystic disease, the lowest in 1 case of simple breast fibrosis. There have been several reports on the outcomes of percutaneous coronary intervention (PCI) for cardiac allograft vasculopathy. Whole-mounts and histological sections were used to code the appearance of 10 developmental events comprising landmarks of development from the early bud stage to late chondrogenesis in the forelimb and the corresponding serial homologues in the hindlimb. Study and results of endodontic treatment of 350 cases treated under local or block anaesthesia

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VHA has now evolved through three generations of applications that support such integration. Catheter ablation for atrial fibrillation in patients with hypertrophic cardiomyopathy. In conclusion, H33342 and PKH26 can be used as fluorescent markers of Schwann cells for short-term studies, for a maximum of 2 weeks, but different markers may be needed for longer experiments.

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In monkeys that had survived 3 to 5 years, only tiny amounts of mercury were detected, which is in contrast to findings from direct exposure, in which large amounts were still found 3 years after exposure. LPA and FN also evoked the formation of focal adhesions and actin bundles, and tyrosine phosphorylation of focal adhesion kinase (FAK) and paxillin. betaB(2)-crystallin protein was partially purified from and its identity confirmed in rat brain, rat testis, and bovine retina. Experiences in the management of over half a thousand cases of bone and joint tuberculosis In addition, the attractive free energies in explicit solvent can also be reproduced with the new model with a correlation coefficient higher than 0.999.

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A recombinant human hemoglobin with asparagine-102(beta) substituted by alanine has a limiting low oxygen affinity, reduced marginally by chloride. The analogous complex with ergothioneine is formed after all the GSH is complexed.

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To determine the response of intrachondrocytic enzymes to specific matrix proteoglycan depletion induced by nonproteolytic enzyme, i.e., chondroitinase ABC. Prospective analysis of the information level of Italian cancer patients. Attitudes of dental students toward dental education and the profession.

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Histophysiological changes in the adrenal in dogs with experimental exclusion of bile from the organism At tailbud stage, these embryos formed a proboscis which is very reminiscent of that formed in hyperdorsalized Xenopus embryos.

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Administration of the serotonin-releasing drug DL-p-chloroamphetamine (PCA) to rats caused a dose-dependent increase in plasma prolactin levels. An 80-year-old woman treated with methotrexate (MTX) and TCZ for RA presented dermo-hypodermitis on her left leg 8 days after receiving her 13th infusion of TCZ. From the possible methods for assay of theophilline two nonaqueous titrations are compared. This article discusses how education can change the culture around the delivery of compassionate care. Antiprogestins possess a potent antitumor activity in hormone-dependent experimental breast cancer models.

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Latrunculin with a highly oxidized thiazolidinone ring: structure assignment and actin docking. Community-based perceptions of emergency care in Zambian communities lacking formalised emergency medicine systems. sativa varieties, a pattern that has not been reported for other crop species. The household garbage in the western coast region of Turkey and its relationship with the socio-economic characterstics. In the ARI maps, all the normal children exhibited a short-ARI area on the left and a long-ARI area on the right side of the chest.

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Effects of policosanol treatment on the susceptibility of low density lipoprotein (LDL) isolated from healthy volunteers to oxidative modification in vitro. Zika congenital syndrome is seen in infants whose mothers had asymptomatic infection.

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Mullerian inhibiting substance inhibits breast cancer cell growth through an NFkappa B-mediated pathway. The lipid composition of MLBs is mainly amoebal in origin, suggesting that MLB formation is a protozoa-driven process that could play a significant role in amoebal physiology. When movements involved both the arms and the legs, the benefit of a visual beat relied only on the latter. Women with perimenopause-related depression were randomized in a double-blind parallel design to receive either 17beta-estradiol or placebo for 3 weeks.

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Stellate-shaped or elongated NG2-positive cells also were detected in chronic MS lesions. This case emphasizes the need for thorough sonographic and laparoscopic observation in order not to miss the presence of bilateral ectopic pregnancy. For validation, phantom and in vivo experiments are performed at 3T. It is thought that, the bacteria in this form may have an important role in recurrent and drug resistant infections as well as infections of unknown origin.

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All patients underwent biplane CA and MRA with use of a gadolinium-enhanced technique. The effects of ascorbic acid and mannitol on induced red blood cell aggregation. Electron microscopy revealed that Cu,ZnSOD was largely localized in the periplasm in polar bays. The engineering effects of fluids flow on freely suspended biological macro-materials and macromolecules.

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orf2 encodes a resolvase/invertase, and orf5 is a homolog of the macrolide-streptogramin B resistance gene msr(SA). Surgery for a ruptured appendix with 2 drainage tubes lasted for 75 min was uneventful.