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Topiramate
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Topiramate

Topiramate is the brand name of Topiramate, an anticonvulsant drug used to prevent seizures and reduce the frequency of migraines. While its exact mechanism of action is unknown, studies suggest Topiramate might alter the production or action of neurotransmitters in the brain, suppressing the abnormal activity of the nerves in the brain that cause seizures or preventing the abnormal activity from spreading to other nerves. Other research has suggested that it might suppress the nerves directly, thereby making them less likely to fire. The Food and Drug Administration (FDA) approved Topiramate to treat seizures in 1996.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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Topiramate is used alone or together with other medicines to help treat certain types of seizures (eg, partial seizures, tonic-clonic seizures, or Lennox-Gastaut syndrome). This medicine will not cure epilepsy and will only work to control seizures for as long as you continue to take it. It is also used to help prevent migraine headaches.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Capsule, Extended Release
  • Tablet
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Given evidence that emotion dysregulation may affect physical health by altering physiological functioning, one mechanism that warrants examination is emotion dysregulation. A quantitative enzyme-linked immunoassay for the detection of 2, 6-dichlorobenzamide (BAM), a degradation product of the herbicide dichlobenil. Tyrosine phosphorylation of c-Cbl occurred within 20 s after stimulation and reached maximum levels within 3-5 min. The findings will also assist HIV services to align with broader public health goals related to increasing ART use and improving quality of life among people living with HIV.

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The likely contribution of this reflex to the control of movement is discussed. Detection of biological threat agents by immunomagnetic microsphere-based solid phase fluorogenic- and electro-chemiluminescence. EBER-1 was detected in nuclei of tumor cells in 8/9 cases of MTL and LMP-1 was found on membrane and in cytoplasm of tumor cells in 7/9 cases of MTL.

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To facilitate the adoption of UKPDS findings, clear guidelines are needed, providing specific recommendations about subgroups of patients showing a higher risk of complications as well as of inappropriate care. To test the hypothesis that dairy farms certified in the Milk and Dairy Beef Quality Assurance Program (QAP) were more likely to use prudent drug management practices than farms that were not certified. Childhood mortality clearly increased after the Gulf conflict and under UN sanctions in the south/centre of Iraq, but in the autonomous region since the start of the Oil-for-Food Programme childhood mortality has begun to decline.

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In addition, expression of the mRNA that encodes the endogenous agonists and antagonists for CNS melanocortin receptors is regulated by changes in energy balance and body-adiposity signals. More importantly, the actuators show a pronounced increase of conductivity due to the deformation induced by the moisture change, which allows the integration of a moisture-sensitive actuator and a humidity sensor. Neutralizing anti-interleukin (IL)-6 and tumor necrosis factor-alpha antibodies inhibited coculture conditioned medium-induced MMP-1 production by VSMCs and THP-1 cells.

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To analyze this innovative contact mechanism, particle velocity synthesis theory and contact force analysis using Hertz contact model are carried out. Quantum diffusion dynamics in nonlinear systems: a modified kicked-rotor model. Each of PAF, ACTH, or FRK eliminated the cortisol response to OAG plus A23187, whereas that to FRK was unaffected. To our knowledge, this is the first example in which cytoprotection by resveratrol has been demonstrated by EPR spin-trapping competition kinetics to be due to its scavenging of the radicals responsible for the toxicity of a prooxidant. As a result, the present study was undertaken to investigate the kinetics of the efficacy mediated by the IFN-alpha1 transgene following ocular challenge with HSV-1.

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In paleopathology, HLs are used to reconstruct health status of past populations. Second drugs were added if needed (metoprolol and prazosin, respectively). Histopathological changes in malignant melanoblastoma of the choroid after light-coagulation. At 1 nmol, changes in blood pressure and HR were evident at 5 min, and remained for 45 min after injection.

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The large difference in hydration changes by both BamHI and EcoRI could be attributed to these dissimilar secondary structural features, as well as the functional differences of the two endonucleases during site-specific DNA recognition. Decrease of disease activity under ineffective therapy in DMARD-naive patients with early rheumatoid arthritis: role of antibody profiles and carriage of the HLA shared epitope in predicting decrease of disease activity. In neurons in which responses to TP stimulation were inhibited, responses elicited by electrical stimulation of the mesencephalic reticular formation (MRF) were also inhibited. Curvature distribution in all prokaryotes of the first group indicated a substantial fraction of promoters characterized by intrinsic DNA curvature located within or upstream of the promoter region. CRISPR/Cas9 is the latest synthetic endonuclease that has revolutionized basic research by allowing facile genome editing in prokaryotes and eukaryotes.

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Many of the monoclonal antibody preparations showed specificity toward the carbohydrate moiety of the glycopeptides and crossreacted immunologically with various glycoprotein preparations, whereas some were specific to the glycopeptides. Dynamic positron emission tomography (PET) is a powerful tool that provides useful quantitative information on physiological and biochemical processes. The obese patient: an acceptable candidate for outpatient anesthesia. Experiments using a duct with a finite section of tensioned membrane are compared with the propagating modes pertaining to the infinite membrane model.

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Toddler temperament and prenatal exposure to lead and maternal depression. Effect of exogenous melatonin on mood and sleep efficiency in emergency medicine residents working night shifts. The tests provide new diagnostic tools for identifying Neisseria infections. Preleukemic cells were located mainly among four out of 21 fractions tested, consisting mostly of 10 to 14 micrometers size cells. Progressive multifocal leukoencephalopathy (PML) is one of the major risks of natalizumab therapy.

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Oestradiol valerate and 17 beta-oestradiol are virtually dose-equivalent. Predictive control of muscle responses to arm perturbations in cerebellar patients.

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The data show that mouse bone marrow potentiator activity is a variant of IL-6 and with the potential to enhance megakaryocyte growth. In a double blind study of the effects of low doses of caffeine on aggression, rats were housed four per cage, and aggressive behavior against an intruder was recorded during baseline and following administration of 2.5, 5, 10, and 20 mg/kg caffeine. Oxidative stress and protein glycation are closely related processes that may contribute to the development of complications in diabetes mellitus. Temporal stability of psychophysiological stress profiles: a re-analysis using intraclass correlation coefficients.

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Capsaicin receptor TRPV1 and wasabi receptor TRPA1 are expressed in the unmyelinated C fiber nociceptors and activated by various nociceptive stimuli causing pain in our body. The objective of the study was to describe the evolution of growth and skeletal age of a brother and sister of Moroccan descent with a homozygous GHRH-R mutation who presented at an advanced age (16 and 14.9 yr, respectively) and pubertal stage (Tanner stage G4 and B3, respectively) with a height of -5.1 sd score and -7.3 sd score on treatment with a combination of GH and GnRHa for 2.5 and 3 yr followed by GH alone. The effect of this experimental infection was evaluated on circulating leukocytes, nasal-derived mediators, and markers of bronchial inflammation that were obtained by bronchoscopy and lavage. Negative bias and aberrant neural processing of emotional faces are trait-marks of depression but findings in healthy high-risk groups are conflicting. Between T0 and T1, the cephalometric analysis showed a significant decrease of the angulation of the upper central incisors to the SN line and to the palatal plane in GrE together with a significant increase of the lower incisors to the mandibular plane (IMPA).

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GBV-C/HGV is frequently transmitted from mothers to infants in the general population. Forty sound and carious primary and permanent teeth, extracted from children and adolescents of Davangere city, were collected. In view of its variability in pharmacokinetics and the potential for toxicities, serum concentrations often are measured. The distal degree of carotid stenosis was assessed by comparison of the diameter of the distal internal carotid artery obtained intraoperatively with the measurements of the plastic specimens (1 mm vascular wall thickness of distal internal carotid artery was taken into account). Correction of ventricular late potentials with drug and non-drug methods in patients with essential hypertension

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Comparison of plasma and saliva concentrations of lamotrigine in healthy volunteers. Fluorescence ratio imaging is a non-invasive technique for studying the formation of microgradients in immobilised bacterial colonies. Vaccine adjuvants, delivery systems and therapeutic vaccination are likely to be the areas of major progress in the future. Bilioenteric fistulas are the abnormal communication between the bile duct system and the gastrointestinal tract that occurs spontaneously and is a rare complication of an untreated gallstone in the majority of cases. Therefore, elucidating the signaling events immediately downstream of DELLA is key to our understanding of how GA controls plant development.

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In case of hunger strike legal standards cannot fully replace psychological insight, professional ethics and conscience, however. Descriptive statistics, student t-test, variance and correlation analysis were used for assessment of the data. This case calls attention to the rare condition of congenital nodular calcification of the skin. Transcription factors (TFs) play key roles in controlling gene expression.

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The anatomic basis of the injury to the extensor carpi radialis brevis origin appears to be multifaceted, involving hypovascular zones, eccentric tendon stresses, and a microscopic degenerative response. These comprised 1520 men and women living in London who were randomly selected for the national survey of sexual attitudes and lifestyles and 2414 heterosexual men and women who presented to the GUM clinic with gonorrhoea. Uptake and transport of horseradish peroxidase by cochlear spiral ganglion neurons. They were aligned parallel with the thick actin bundles that appeared as an initial stage of developing myofibrils. We conclude that, in addition to increasing endothelial nitric oxide biosynthesis in placental stem villous arteries, adrenomedullin induces release of an endothelium-derived constricting factor.

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NAIs were related to the histopathologic stage: the highest NAIs were found in 8 cases of classic fibrocystic disease, the lowest in 1 case of simple breast fibrosis. There have been several reports on the outcomes of percutaneous coronary intervention (PCI) for cardiac allograft vasculopathy. Whole-mounts and histological sections were used to code the appearance of 10 developmental events comprising landmarks of development from the early bud stage to late chondrogenesis in the forelimb and the corresponding serial homologues in the hindlimb. Study and results of endodontic treatment of 350 cases treated under local or block anaesthesia

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To determine the response of intrachondrocytic enzymes to specific matrix proteoglycan depletion induced by nonproteolytic enzyme, i.e., chondroitinase ABC. Prospective analysis of the information level of Italian cancer patients. Attitudes of dental students toward dental education and the profession.

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Administration of the serotonin-releasing drug DL-p-chloroamphetamine (PCA) to rats caused a dose-dependent increase in plasma prolactin levels. An 80-year-old woman treated with methotrexate (MTX) and TCZ for RA presented dermo-hypodermitis on her left leg 8 days after receiving her 13th infusion of TCZ. From the possible methods for assay of theophilline two nonaqueous titrations are compared. This article discusses how education can change the culture around the delivery of compassionate care. Antiprogestins possess a potent antitumor activity in hormone-dependent experimental breast cancer models.

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Latrunculin with a highly oxidized thiazolidinone ring: structure assignment and actin docking. Community-based perceptions of emergency care in Zambian communities lacking formalised emergency medicine systems. sativa varieties, a pattern that has not been reported for other crop species. The household garbage in the western coast region of Turkey and its relationship with the socio-economic characterstics. In the ARI maps, all the normal children exhibited a short-ARI area on the left and a long-ARI area on the right side of the chest.

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Effects of policosanol treatment on the susceptibility of low density lipoprotein (LDL) isolated from healthy volunteers to oxidative modification in vitro. Zika congenital syndrome is seen in infants whose mothers had asymptomatic infection.

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