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Tenofovir is an acyclic nucleotide analogue reverse-transcriptase inhibitor structurally similar to the nephrotoxic drugs adefovir and cidofovir. Tenofovir is widely used to treat HIV infection and approved for treatment of hepatitis B virus. Despite initial cell culture and clinical trials results supporting the renal safety of Tenofovir, its clinical use is associated with a low, albeit significant, risk of kidney injury. Proximal tubular cell secretion of Tenofovir explains the accumulation of the drug in these mitochondria-rich cells. Tenofovir nephrotoxicity is characterized by proximal tubular cell dysfunction that may be associated with acute kidney injury or chronic kidney disease. Withdrawal of the drug leads to improvement of analytical parameters that may be partial. Understanding the risk factors for nephrotoxicity and regular monitoring of proximal tubular dysfunction and serum creatinine in high-risk patients is required to minimize nephrotoxicity. Newer, structurally sim.

Other names for this medication:
Tenofovir, Atripla, Tenvir, Trioday, Truvada, Viraday, Viread,

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Tenofovir is used in combination with other medicines for the treatment of the infection caused by the human immunodeficiency virus (HIV). HIV is the virus that causes acquired immunodeficiency syndrome (AIDS).

Tenofovir will not cure or prevent HIV infection or AIDS. It helps keep HIV from reproducing and appears to slow down the destruction of the immune system. This may help delay problems that are usually related to AIDS or HIV disease from occurring. Tenofovir will not keep you from spreading HIV to other people. People who receive this medicine may continue to have some of the problems usually related to AIDS or HIV disease.

Tenofovir is also used to treat chronic (long-term) hepatitis B virus (HBV) infection.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet
  • Powder

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A novel sequence polymorphism in exon 8 of the human vitamin D-binding protein (GC) gene in an African population. Sleep apnea may interact endocrine rhythms by a number of mechanisms. For both types of effect, human serum could be replaced by normal hamster serum but not by rabbit serum. 252, 274-277, 1998) that the expression of mSin3A but not mSin3B protein is induced during neuronal apoptosis. The 2 manipulative acanthocephalans, Polymorphus minutus and Pomphorhynchus laevis, use the amphipod Gammarus pulex as an intermediate host, and their infection intensity and incidence among G.

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Redesign and Validation of Sisom, an Interactive Assessment and Communication Tool for Children With Cancer. MR imaging is unsurpassed in demonstrating early structural and proliferative changes that occur in inflammatory and related arthritides, and in evaluating complications that can cause significant morbidity, and even death. This paper critically reviews research done to date on cognitive and functional outcome following TBI in the elderly. Accordingly, AEA and 2-AG likely play a role in processes governed by the LDT, including control of states of cortical gamma band activity seen in alert, aroused states, as well as cortical and motor activity characteristic of REM sleep. Endoscope employed was the third generation sialoendoscope (Nahlieli Sialoendoscope, Karl Storz, Tuttlingen, Germany).

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NV1042-infected cells, as detected by 5-bromo-4-chloro-3-indolyl-beta-d-galactopyranoside staining for Lac Z expressed by the virus, were present in prostate tumors 1 week after the final virus injection and viral DNA was detected at 2 weeks after final virus injection by real-time PCR in primary and metastatic tumors but not in liver or blood. But the shortening of clotting time by chitosan microspheres may be related to not only platelet aggregation, but also erythrocyte aggregation.

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Exonucleolytic processing of small nucleolar RNAs from pre-mRNA introns. Here, we review molecular mechanisms that integrate spatial and temporal information in day-length-dependent flowering.

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Repetitive pulsed dye laser treatments improve persistent port-wine stains. For the design of a new separation process based on unfolding and refolding of protein, the partitioning behaviour of proteins was studied in thermoseparating polymer two-phase systems with varying pH and temperature. By applying mathematical principles, viral serum half-life was estimated to be 3.0 hours and viral production rat was calculated to be 1.0 x 10(12) virions per day.

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DNA-based immunization is a promising antiviral strategy to prevent or treat persistent viral infections. Proximal tibial metaphyseal fractures are an uncommon injury that occur in skeletally immature dogs from minimal trauma. Anesthesia services for surgical procedures may or may not be personally performed or medically directed by anesthesiologists. Several HFA-MDIs have reached the market and the transition to replace existing CFC-MDIs is now underway. This sequestration of normal MAPs by the abnormal tau results in the breakdown of the microtubules.

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Many hypotheses have been posed as to whether PNH and PIG-A mutations result in an intrinsic survival benefit of CD55(-)/CD59(-) cells or an extrinsic permissive environment that allows for their clonal expansion within the bone marrow compartment. Our aim was to determine risk and predictive factors related to carotid restenosis post carotid angioplasty and its association to recurrent cerebrovascular events.

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