Atorvastatin is used together with diet, weight loss, and exercise to reduce the risk of heart attack and stroke and to decrease the chance that heart surgery will be needed in people who have heart disease or who are at risk of developing heart disease. Atorvastatin is also used to decrease the amount of fatty substances such as low-density lipoprotein (LDL) cholesterol ('bad cholesterol') and triglycerides in the blood and to increase the amount of high-density lipoprotein (HDL) cholesterol ('good cholesterol') in the blood. Atorvastatin may also be used to decrease the amount of cholesterol and other fatty substances in the blood in children and teenagers 10 to 17 years of age who have familial heterozygous hypercholesterolemia (an inherited condition in which cholesterol cannot be removed from the body normally). Atorvastatin is in a class of medications called HMG-CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.

Accumulation of cholesterol and fats along the walls of your arteries (a process known as atherosclerosis) decreases blood flow and, therefore, the oxygen supply to your heart, brain, and other parts of your body. Lowering your blood level of cholesterol and fats with atorvastatin has been shown to prevent heart disease, angina (chest pain), strokes, and heart attacks.

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Pyrazidol, inkazan, imipramine, and iproniazide also had an inhibitory effect on the enzyme activity, but their action was not selective. These studies, which provide crucial information regarding the structural and conformational requirements for ligand-receptor interactions, will be of considerable importance for the design of novel UT ligands with increased selectivity, potency and stability, that may eventually lead to the development of innovative drugs. For small intrinsic dimensionality of the data and certain distributions of components of the weight vector the single layer perceptron can be trained even with very short learning sequences.

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Gene transfer of human TNF alpha into glioblastoma cells permits modulation of mdr1 expression and potentiation of chemosensitivity. To determine whether multifocal electroretinograms (mfERGs) can provide an index for identification of glaucomatous optic neuropathy in patients with normal-tension glaucoma (NTG).

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Age-associated changes in acid phosphatase characteristics in rat ventral prostate and other organs. Effect of rancid fodder on reproductive apparatus and on lactation in cattle Phospholipid-mimic oxaliplatin prodrug liposome for treatment of the metastatic triple negative breast cancer. Can the pentitol-hexitol theory explain the clinical observations made with xylitol? Local effect of five-percent chromic acid on the gingiva and teeth of mice, rats and hamsters.

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Antivenom produced from horses is the main treatment for snakebites, but it may cause numerous clinical side effects and have other disadvantages involved in their production such as the welfare of animals. While not conclusive, the literature supports using soft tissue preserving techniques, bicortical proximal fixation, and fixation spanning the length of the femur. Preliminary report on the effect of complete mouth rehabilitation on oral lactobacilli counts. Preoperative care, postoperative care and anesthesia in thoracic surgery

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As a practical example, this newly developed SWDMI protocol was applied to rapid and large scale analysis of APTS labeled monoclonal antibody N-glycans using a short (20cm effective length) capillary column. Dose-response curves (grains per nucleus versus UV dose) were established and analyzed by linear regression.

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Estimating the sensitivity of passive surveillance for HPAI H5N1 in Bayelsa state, Nigeria. Midgut protease levels did not differ 6 days post-infection in flies maintaining infections versus flies clearing infections. The concentration gradient of O and OH ions was detected in the through-thickness direction of coatings. Prior to actual application, the threshold conditions for each color are discussed, in order to acquire a stable and reproducible photoplethysmogram (PPG) signal. When core particles are dissociated in the stopped-flow cuvette, the high CD deviation corresponding to the dissociated state is reached in the first millisecond, which means that the dissociation process is completed within the dead time of the apparatus which is approximately 1 ms.

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If the distance of both lines is near or the same, that means narrow cervical canal. Over a period of 12 years, 100 patients with a confirmed ulcer recurrence after prior gastric resection underwent a standardized surgical procedure. The first case applies SEM/EDX to characterize microscopic gold particles recovered from clothing of suspects involved in goldsmith robberies. Taking into account the potential auditory damage induced by solvent exposure due to the neurotoxic properties of such substances, the present research aimed at studying the possible auditory processing disorder (APD), and possible hearing difficulties in daily life listening situations that solvent-exposed workers may acquire.

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In addition, the residues in the binding site of each ligand contribute differently to binding of the human versus the mouse IL-1R. Unlike cardiovascular activities of alpha-methylene-gamma-butyrolactones in which a gamma-methyl substituent is necessary for vasorelaxing effect while a phenyl or a halogen-substituted phenyl is prefer for the antiplatelet activities, a gamma-biphenyl substituent proved to be the best for their cytotoxicities against various cancer cell lines tested. In this observational study, we evaluated core temperatures and intraoperative thermal management in patients undergoing spinal or epidural anesthesia. Extravesical transitional cell carcinoma as a result of implantation after perforation of the bladder. Structural, morphological, biochemical studies of the organic matrix of developing and mature enamel.

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Both degeneration and mononuclear-cell inflammation are components of the pathology, but how each relates to the pathogenesis remains unclear. Different techniques for delivery of the priming antigen offer different advantages. The pathogenesis of pancreatitis was possibly due to a pure duodenal content reflux through the papilla of Vater. Intellectual disability and non-compaction cardiomyopathy with a de novo NONO mutation identified by exome sequencing.

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The authors believe that fair, accountable, scientific and rigorous research on complementary therapies will benefit physicians and patients. Distributions of differences between machine measurements and institutional TPS values were generated for basic dosimetric parameters.

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Effect of diethylstilbestrol on the oxytocic activity of the serum in threatened abortion of endocrine origin The emotional as well as the physical impact of gynecologic cancer may be particularly felt in the area of sexual attitudes and behavior. However, a possible development of craving for the drug and the risk of abuse and physical dependence have been reported in subjects who used gamma-hydroxybutyric acid for different reasons, including alcoholism therapy.

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Evolution of pre- and post-copulatory traits in female Drosophila melanogaster as a correlated response to selection for resistance to cold stress. A LPG explosion in a vented enclosure with built-in obstacles is strong enough to make the brick and mortar wall with a thickness of 370mm damaged.

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Subjectively divided tone components in the gap transfer illusion. At each setting, the subjects were asked to perform 12 activities of daily living. The extended combined model accurately calculates prehepatic insulin appearance.

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This result suggests that the host has an influence on the type of DI RNA that accumulates during consecutive high multiplicity of infection passages. High-copy cDNA amplification of minimal total RNA quantities for gene expression analyses. In mammals, one type of substitutional RNA editing, characterized by site-specific base-modification, was shown to modulate important physiological processes.

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Cultivation and properties of T-strains of mycoplasma associated with nongonococcal urethritis. One hundred eleven patients who underwent PETLD between January 2016 and October 2016 were included in this study.

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As a supplement to antibiotic treatment, all three patients received corticosteroids for the initial 2 days of treatment, and this may have contributed to the unusual course of the disease in our patient. Homotypic and heterotypic coupling mediated by gap junctions during glial cell differentiation in vitro. By knock down of LPA1 and LPA3 in HUVECs, LPA-enhanced IL-1beta mRNA expression was significantly attenuated. Prediction results on 3 able-bodied subjects and 3 SCI patients demonstrate promising performances. Because the order of neurogenesis is conserved, the most likely brain alteration resulting from selection for any behavioral ability may be a coordinated enlargement of the entire nonolfactory brain.

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aeruginosa was more sensitive to hydrogen peroxide as SCP (96h EC50:0.9-1.0mgL(-)(1) H2O2) than the eukaryotic alga P. Which silicate cements can be recommended to the dentist according to the FDI specification No. Phylogeography of Iris missouriensis (Iridaceae) based on nuclear and chloroplast markers. Prevalence of helminth parasites was carried out in both male and female villagers graded into three age groups (5-14 years, 15-25 years, 26-55 years).

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The aim was to develop and evaluate a pre-IOLP CV screening protocol. Retrospective review of responses received during public consultation for 183 pieces of draft guidance, and subsequent changes made. The results of this paper highlight the significant antimicrobial action of a natural compound, hydrosol of Thymbra capitata, against both planktonic and biofilm cells of a common foodborne pathogen. Adenine nucleotides were tested as effectors of peroxisomal and mitochondrial citrate synthase from Agave americana leaves in the presence of different concentrations of acetyl-CoA and oxalacetate substrates. Comparative completeness and correspondence of cancer mortality data as collected by ISTAT and Cancer Registries.

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In the course of 3 vaccinations, the concentration of serum immunoglobulins, chemotaxic activity of leukocytes, and blood lymphocyte reactivity to mitogens do not change. We have created a hybrid computational model comprised of ordinary differential equations and stochastic simulation. Using the public available data of soft tissue sarcoma from The Cancer Genome Atlas, we developed a cross-validation procedure for identifying a gene signature and predicting radiosensitive patients through.

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From these studies, it can be concluded that the clostridial neurotoxins responsible for tetanus and botulism block neuroexocytosis via the proteolytic cleavage of specific components of the neuroexocytotic machinery. The stereoscopic image analysis of fluorescence-labeled chondrocyte cells for cytoplasm and nucleus was performed for the quantitative determination of spatial cell distribution as well as cell aggregate size in the collagen-embedded culture.

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These data suggest that homologous mitotic recombination, induced by O6-MeG in a subpopulation of cells heterozygous for p53 mutation, rendered the cells homozygous for loss of p53 activity, that this allowed the cells to form foci, and that although loss of p53 is not sufficient for malignant transformation, it predisposes cells to acquire the additional changes needed for such transformation. Dietary toxicity testing with 2-wk-old chicks indicated an 8-d LC50 in excess of 15,000 ppm.

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It is of therapeutic interest to know whether the influence of ketoconazole can be reduced by administration on an occasion different in time to CYP3A substrates. We examined differences in the prevalence of HIV infection and unawareness among MSM in 2011 and 2014 using data from the National HIV Behavioral Surveillance System, 2011 and 2014.

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However, even at this time, the synthesis and secretion of IgM were not affected by virus infection. Moreover, the ability of L-NAME to unmask a pressor effect of murine leptin in anaesthetized rats may not be apparent in the conscious state. Pro-urban and pro-rich inequalities were observed for coverage of institutional SBA deliveries.

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She had previously complained of ocular pain and blurred vision. The present experiments were designed to examine the site of action of the alpha 2-adrenoceptor agonist, clonidine, and the alpha 2-antagonist, yohimbine, on the salivary secretion response to parasympathetic and sympathetic stimulation in the cat submandibular gland (SMG). The absorbed fractions (AF) of electrons in sensitive layers of human respiratory tract were calculated in this paper. Multiple myeloma (MM) is a B-cell malignancy originating from pre-switched, follicle center B-lymphocytes which differentiate to plasma cells accumulating in the bone marrow. ADRs during treatment courses were reported spontaneously by attending physicians.

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This was a randomized, placebo-controlled study of two different types of external aromatherapy tabs (lavender-sandalwood and orange-peppermint) compared with a matched placebo-control delivery system. To determine the correlation of PaCO2 and ETCO2 during operations for lumbar disk herniation in prone position: the influence of position and deliberate hypotension. A systematic review of the evidence regarding LI-ESWT for patients with ED was undertaken with a meta-analysis to identify the efficacy of the treatment modality.

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We studied risk factors of 200 consecutive patients with symptomatic lacunar infarcts diagnosed by magnetic resonance imaging. Using this novel method, we successfully identified taxonomic groups of several uncultured MTB and one novel magnetotactic Gammaproteobacteria strain, SHHR-1, from natural environments.

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The relation between antibacterial activity and structure of substituted desoxybenzoins Associated costs and the requirement for a surgical procedure should encourage the continued evaluation of new noninvasive modalities and the further evolution of endoscopic ultrasound. Roentgen kymographical study of the pulsatory co-movement in the kidneys

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Aberrant internal carotid artery (aICA) is an anatomic anomaly whereby the internal carotid artery courses through the tympanic cavity without separation by bone. Available tissue samples were split into a training set, for learning the CNN parameters, and test set, for evaluating its performance. However, it is unknown if DSLNT also protects human preterm infants. Organoleptic evaluation of Stevia leaf herbarium samples for sweetness.

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Influence of Distance to Scene on Time to Thrombolysis in a Specialized Stroke Ambulance. The suppression of tumor growth was due to the inhibition of STAT3 phosphorylation and induction of tumor cell death.

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The nuclear pore complex is a prominent structural component of the nuclear envelope that appears to regulate nucleoplasmic molecular movement. Adipose tissue lipin-1 expression is correlated with peroxisome proliferator-activated receptor alpha gene expression and insulin sensitivity in healthy young men. The purpose of this study was to review the results of lower extremity revascularization in patients with end-stage renal disease and to determine in these patients the functional benefit and cost of an aggressive approach to limb preservation. Low Glycemic Index Prototype Isomaltulose-Update of Clinical Trials.

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Chronic inflammatory periodontal disease is known to be under the control of the immune response. We further demonstrated that matriptase can convert hepatocyte growth factor/scattering factor to its active form, which can induce scatter of Madin-Darby canine kidney epithelial cells and can activate c-Met tyrosine phosphorylation in A549 human lung carcinoma cells.

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Additional research is needed to determine normative values for multidimensional voice program scores and other assessments in the elderly population. Family members are carriers of the same E1053K variant, some even in a homozygous state, but surprisingly did not exhibit any pathological cardiac phenotype. We empirically demonstrate linear scalability and linear memory usage on random graphs of up to 15000 nodes. The results cannot be explained if it is assumed that animals rely on static cues, such as those derived from individual postures, in order to discriminate between the actions of another animal. A quantitative structure--activity relationships model for the acute toxicity of substituted benzenes to Tetrahymena pyriformis using Bayesian-regularized neural networks.

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Immunization of ovarian cancer patients with a synthetic Lewis(y)-protein conjugate vaccine: a phase 1 trial. On the mechanism of liquefaction of tubercles: conditions regulating autolysis of tuberculous caseous tissue in vitro. Our survey identified 100 medicinal plants from Dagala region and of these, 16 species has economic potential that could benefit both MSP and Dagala communities. Formulation and Evaluation of Oral Dissolving Films of Amlodipine Besylate Using Blends of Starches With Hydroxypropyl Methyl Cellulose.

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Children in working low-income families in California have some of the worst access problems. For the entire superfamily, we have used a new predictive program to identify the transmembrane domains.

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Buried water molecules close to the binding sites suggest possible pathways for proton uptake and release. PKC activation by melatonin modulates vimentin intermediate filament organization in N1E-115 cells.