Atocor did not affect maximal exercise oxygen consumption or the anaerobic threshold. Finally, treatment of rats with Atocor caused down-regulation of aortic AT1 receptor mRNA expression and reduced aortic superoxide production in vivo. The relation between ABCA1 SNPs and the lipid-lowering response to Atocor (10 mg/day/4 weeks) was also evaluated in 141 hypercholesterolemic (HC) individuals.
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