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Aczone (Dapoxetine)
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Dapoxetine

Aczone a selective serotonin reuptake inhibitor is a new chemical entity for the treatment of premature ejaculation. Since no systematic studies on design and development of Aczone hydrochloride tablets are available in literature, we propose to develop a suitable formulation to characterize in vitro release profile of Aczone hydrochloride. The aim of the present study was to formulate various formulations of immediate release tablets of Aczone Hydrochloride using different excipients by direct compression and wet granulation method. The granules and tablets of Aczone HCl were evaluated for various pre and post compression parameters like Angle of repose, Compressibility index, Hausner's ratio, Tablet hardness, Thickness, Friability, and chemical parameters. Punches of different size were used to obtain the desired shape, ease of swallowing of tablets, to improve aesthetic value in terms of appearance and shape of tablets. To match dissolution profile of test formulation with innovator, drug particle size is reduced from D 90-158 µ to D 90-45 µ, which resulted in an increased surface area exposed to the dissolution medium. Final formulation was evaluated for multimedia dissolution in three different media and dissolution data was found satisfactory. Accelerated stability studies conducted for 2 Months at 40°C and 75% RH and were found within specification.

Other names for this medication:
Dapoxetine, Actinex, Aczone, Dapoxetin, Dapoxetina, Dapsone, Dejac, Duraject, Duralast, Poxet, Priligy, Tadapox, Viglast, Westoxetin, Xydar,

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Gelnique, Repaglinida, Stemzine, Larb, Gliben, Aldalix, Clindamicina, Duodart, Lexapro, Sitavig, Prevas, Befol, Spironolactona, Omnexel, Myclin, Bristamox, Mobigel, Velaxin, Lyflex, Topictal, Lovequin, Cipro, Regan, Altin, Epratenz, Azelastin, Maxen,

Aczone is a selective serotonin reuptake inhibitor medicine which has specially been developed for the treatment of premature ejaculation. You have to take it 1-3 hours before you have sex. It starts to work very quickly, so it is taken when you anticipate having sex, rather than every day.

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An Oxygenated and Transportable Machine Perfusion System Fully Rescues Liver Grafts Exposed to Lethal Ischemic Damage in a Pig Model of DCD Liver Transplantation. A significant dose-response relationship between SCE and EO dose was recorded up to 35 micrograms/ml, the highest dose tested. Antimicrobial activity of the newly obtained derivatives such as, for example, 4-(adamant-1-ylmethoxycarbonyl)-N-(5-carboxypentamethylene)p hthalimide or 4-(adamant-1-ylmethoxycarbonyl)-N-(L-alanyl)phthalimide was tested against Staphylococcus aureus, Bacillus sp., Micrococcus flavus and Enterococcus faecium. The enhanced neutrophil adhesion and the elevated medium levels of TNF-alpha, but not IL-8, were markedly reduced by inserts that prevented direct TC/EC contact and by monoclonal antibodies directed against vascular cell adhesion molecule-1 (VCAM-1) or very late antigen-4 (VLA-4). Biochemical and radiological properties of sellar and parasellar lesions are quite similar in some instances.

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We analyzed Michaelis--Menten pharmacokinetic parameters of phenytoin with and without the coadministration of allopurinol (150 and 200 mg/day) in a child with Lesch--Nyhan syndrome. To evaluate if antimitochondrial type 5 antibodies (AMA5) might be included among antiphospholipid syndrome (APS) markers. Using a probability sample from a 2001 Youth Risk Behavior Survey of Asian-Pacific Islander youths in Guam, this brief study examined the outcomes for methamphetamine use on aggression and risky sexual activities. Thermal adaptation in biological membranes: is homeoviscous adaptation the explanation? Surgery and radiation therapy of triple-negative breast cancers: From biology to clinics.

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Stress, in the form of mechanical, psychological or immunological insult to an organism results in the activation of the hypothalamo-pituitary-adrenal (HPA) axis initiated by the hypothalamic release of corticotropin-releasing factor (CRF). Through comparative genomics, we identified genomic islands, phage regions, bile salt and acid stress resistance genes, bacteriocins, adhesion-related and antibiotic resistance genes, and genes encoding proteins that are putatively secreted, expressed in vitro and absent from IL1403. Extensive research on polymer solar cells has provided insight into the factors governing device-level efficiency and stability. Analysis of some secondary metabolites, total phenolic, flavonoids, flavonols, and procyanidins, was performed using different solvents following the increased gradient of polarity. Treatment of tumor cells engineered to secrete or display chaperones may be of benefit, particularly in the area of cell-based vaccine development.

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The use of adjunctive psychotropics and the costs of polypharmacy in patients randomized to receive risperidone or quetiapine were compared in a placebo-controlled double-blind study conducted in India, Romania, and the United States. The significance of the disturbance of tryptophan metabolism in radiation injury

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Qualitative analysis of tuberculosis morbidity in relation to the time element and contagious milieu A comparative study of the quality attributes of a variety of commercially available brands of tea were performed using the biosensor and conventional analytical techniques such as spectrophotometry. Our results support that the loss of functional SDF-1/CXCR4 signaling pathway in NSCs/NPCs induces exit of cell cycle and promotes premature neural differentiation. Observation of a dynamic crossover in water confined in double-wall carbon nanotubes.

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The irreplaceable nature of the DNA sets it apart from other cellular molecules, and makes it a critical target for age-related deterioration. Muscle strength and mass of lower extremities in relation to functional abilities in elderly adults. Duplication of the gastrointestinal tract: a report of a rare case of mediastinal cyst

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As the model may be readily extended to provide a simplistic accounting of the fluid flow profiles induced during functional loading and other exogenous loading regimes, the approach will enhance the ability to examine fluid flow related mechanotransduction within bone. We discuss the application of the proposed method on clinical data and show initial results. Patient Education and Support During CKD Transitions: When the Possible Becomes Probable. The obtained results may be helpful in recommending parameters for safe femtosecond laser microscopy of living specimens. Non-Covalent Microgel Particles Containing Functional Payloads: Coacervation of PEG-Based Triblocks via Microfluidics.

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In the early neonatal period, adequate sources of zinc can be obtained from breast milk. It led to an obvious inhibition of the c-fos expression in paraventricular nuclei of the hypothalamus, medial and lateral parts of the septum of rats predisposed to emotional stress. Prostasomes isolated from human seminal plasma stimulated the forward motility of buffer-washed, and therewith immobilised, normal human spermatozoa in a dose- and time-related fashion. Dose dependent depression of dehydrogenase activity of duration up to 14 weeks was detected in chondrocytes of all cartilage zones. Effect of oral administration of Butyrivibrio fibrisolvens MDT-1, a gastrointestinal bacterium, on 3-methylcholanthrene-induced tumor in mice.

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