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Aczone (Dapoxetine)

Aczone a selective serotonin reuptake inhibitor is a new chemical entity for the treatment of premature ejaculation. Since no systematic studies on design and development of Aczone hydrochloride tablets are available in literature, we propose to develop a suitable formulation to characterize in vitro release profile of Aczone hydrochloride. The aim of the present study was to formulate various formulations of immediate release tablets of Aczone Hydrochloride using different excipients by direct compression and wet granulation method. The granules and tablets of Aczone HCl were evaluated for various pre and post compression parameters like Angle of repose, Compressibility index, Hausner's ratio, Tablet hardness, Thickness, Friability, and chemical parameters. Punches of different size were used to obtain the desired shape, ease of swallowing of tablets, to improve aesthetic value in terms of appearance and shape of tablets. To match dissolution profile of test formulation with innovator, drug particle size is reduced from D 90-158 µ to D 90-45 µ, which resulted in an increased surface area exposed to the dissolution medium. Final formulation was evaluated for multimedia dissolution in three different media and dissolution data was found satisfactory. Accelerated stability studies conducted for 2 Months at 40°C and 75% RH and were found within specification.

Other names for this medication:
Dapoxetine, Actinex, Aczone, Dapoxetin, Dapoxetina, Dapsone, Dejac, Duraject, Duralast, Poxet, Priligy, Tadapox, Viglast, Westoxetin, Xydar,

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Gelnique, Repaglinida, Stemzine, Larb, Gliben, Aldalix, Clindamicina, Duodart, Lexapro, Sitavig, Prevas, Befol, Spironolactona, Omnexel, Myclin, Bristamox, Mobigel, Velaxin, Lyflex, Topictal, Lovequin, Cipro, Regan, Altin, Epratenz, Azelastin, Maxen,

Aczone is a selective serotonin reuptake inhibitor medicine which has specially been developed for the treatment of premature ejaculation. You have to take it 1-3 hours before you have sex. It starts to work very quickly, so it is taken when you anticipate having sex, rather than every day.

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Development of an estrus synchronization protocol for beef cattle with short-term feeding of melengestrol acetate: 7-11 synch. Eotaxin-2 and colorectal cancer: a potential target for immune therapy.

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An Oxygenated and Transportable Machine Perfusion System Fully Rescues Liver Grafts Exposed to Lethal Ischemic Damage in a Pig Model of DCD Liver Transplantation. A significant dose-response relationship between SCE and EO dose was recorded up to 35 micrograms/ml, the highest dose tested. Antimicrobial activity of the newly obtained derivatives such as, for example, 4-(adamant-1-ylmethoxycarbonyl)-N-(5-carboxypentamethylene)p hthalimide or 4-(adamant-1-ylmethoxycarbonyl)-N-(L-alanyl)phthalimide was tested against Staphylococcus aureus, Bacillus sp., Micrococcus flavus and Enterococcus faecium. The enhanced neutrophil adhesion and the elevated medium levels of TNF-alpha, but not IL-8, were markedly reduced by inserts that prevented direct TC/EC contact and by monoclonal antibodies directed against vascular cell adhesion molecule-1 (VCAM-1) or very late antigen-4 (VLA-4). Biochemical and radiological properties of sellar and parasellar lesions are quite similar in some instances.

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Nucleotide sequence of Acholeplasma laidlawii genome site PG-8B (1000 n.p.), containing topoisomerase IV subunit genes (parE and parC), has been determined. Relationship between cortical electrical and cardiac autonomic activities in the awake lizard, Gallotia galloti. is an infectious necrosis of the sub-cutaneous tissue appearing frequently in surgical or post traumatic contexts. There is a need for a consensus on the optimal management of each of the vast arrays of urethral injuries. However, initial pH was not related to performance on measures of motor impulsivity or working memory.

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Combinatorial mutagenesis and in vivo selection experiments previously afforded functional variants of the AroH class Bacillus subtilis chorismate mutase lacking the otherwise highly conserved active site residue Arg(90). Impact of image guidance on outcomes after external beam radiotherapy for localized prostate cancer.

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An experimental study on the effect of root canal disinfectants to periapical wound healing The spread of the disease in dogs was followed by the emergence of rabies of jackals and cattle in central Namibia, northern Botswana, Zimbabwe and the northern Transvaal. Lymphomatoid papulosis appears to be a range of disorders of the lymphoproliferation of activated T-cells and could include varioliform parapsoriasis and cutaneous lymphoma. An as yet unresolved issue is whether mentalising deficits reflect a characteristic which can also be detected in people at risk for psychosis or people with evidence of subclinical expression of psychosis.

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In addition, other social factors may also affect the utilization of multiple detection modalities. Intraoperative cardiac output, airway pressure, changes in tracheobronchial mucosa, and acid-base balance were monitored.

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We analyzed Michaelis--Menten pharmacokinetic parameters of phenytoin with and without the coadministration of allopurinol (150 and 200 mg/day) in a child with Lesch--Nyhan syndrome. To evaluate if antimitochondrial type 5 antibodies (AMA5) might be included among antiphospholipid syndrome (APS) markers. Using a probability sample from a 2001 Youth Risk Behavior Survey of Asian-Pacific Islander youths in Guam, this brief study examined the outcomes for methamphetamine use on aggression and risky sexual activities. Thermal adaptation in biological membranes: is homeoviscous adaptation the explanation? Surgery and radiation therapy of triple-negative breast cancers: From biology to clinics.

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The use of adjunctive psychotropics and the costs of polypharmacy in patients randomized to receive risperidone or quetiapine were compared in a placebo-controlled double-blind study conducted in India, Romania, and the United States. The significance of the disturbance of tryptophan metabolism in radiation injury

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