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This work introduces a tool for interactive exploration and visualization using MetaTracts. The combined use of different typing methods is beneficial for outbreak investigations.

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Actionable targets found in a single MB biopsy were seldom clonal across the entire tumor, which brings the efficacy of monotherapies against a single target into question. Bayesian evaluation of effect size after replicating an original study.

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Potential role of EDG receptors and lysophospholipids as their endogenous ligands in the respiratory tract. As a practical consequence, patients should be made aware of a possible impairment of their olfactory and trigeminal function under long-term analgesic treatment. However, the precise mechanisms by which IL-33 modulates IBD are controversial.

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Their relationship to morphological malformations, anomalies and functional defects are described. Wheat (Triticum aestivum) storage proteins fold and assemble into complexes that are linked by intra- and intermolecular disulfide bonds, but it is not yet clear whether these processes are spontaneous or require the assistance of endoplasmic reticulum (ER)-resident enzymes and molecular chaperones.

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In terms of FIp target mechanisms, carers receiving FIp were more likely to shift from high to low expressed emotion and less likely to report patient focused criticism or engage in conflict communication than carers randomized to standard care. Mice and cells harboring a mutant allele of c-jun, which has the JNK phosphoacceptor serines changed to alanines (junAA), were used to determine the function of c-Jun N-terminal phosphorylation (JNP) during oncogenic transformation in vitro and in vivo. Even though preliminary, these data show that the use of validated clinical instruments, that focus on the impact of emotional/behaviour problems on everyday life, allows to carefully identify clinically significant psychopathology. The sensitivity and specificity for detecting differentially expressed genes varies substantially for different methods. Excretion of cephaloridine and cephalothin in patients with renal impairment.

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Changes in plasma fatty acid profile in Japanese patients with chronic pancreatitis. This has been done in cases of Rh disease by intervening intrauterine transfusion, by medically treating the fetal arrhythmias, and/or by treating the basic underlying maternal disorder. The stratum corneum is one of the targets showing primary changes after a short contact with detergents. We could not determine which lesion developed first, but the results of the immunoperoxidase staining of plasma cells in both lesions indicate that the origin of the plasmacytoma was probably the same as that of the nodular amyloid. The resulting virtual dissection program of the brain is helpful in better understanding the 3D location and shape of the brain components and it is expected to be used as a CD-title or through Internet as an educational tool for medical students and doctors.

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In mangenose poisoning heavy encephalopathy with pyramidal and extrapyramidal disturbances proved to be progressive, in mercury chronic intoxication cerebellar symptoms and sensitive neuropathy were the most frequent. Prediction of medium-term outcome in cluster B personality disorder following residential and outpatient psychosocial treatment. However, the identification of TG can be sometimes difficult due to the small retention differences between the compounds.

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Amino acid-enriched glucose-insulin-potassium infusion improves hemodynamic function after coronary bypass surgery. Diurnal change of thyroid-stimulating hormone mRNA expression in the rat pars tuberalis.

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Isolated coronoid fractures mostly involved the anteromedial facet of the coronoid process associated with lateral ulnar collateral ligament rupture and medial bone bruising. Ongoing research should clarify the controversies surrounding DCIS and enable us to define the optimal management for this disease. RNA drug targets are pervasive in cells, but methods to design small molecules that target them are sparse. Structure of the glycopeptides of a human gamma 1-immunoglobulin G (Tem) myeloma protein as determined by 360-megahertz nuclear magnetic resonance spectroscopy. On this basis one may envisage a novel route for a MRI location of tumors as it is known that positively charged polyamino acids selectively bind to tumors having a greater negative charge than non-tumor cells.

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The corresponding phase coherence length L phi is typically between 100 and 200 nm at 20 mK. The signaling pathways accounting for the inhibitory effects of compound 2 were also elucidated. The results obtained are compared to those of mezlocillin, azlocillin and fosfomycin, Finally, the importance of the cefsulodin perilymph concentrations in the treatment and prophylaxis of infectious inner ear complications due to the most common pathogens of chronic otitis media as well as in the treatment of certain eye infections is discussed. Finally, this review presents evidence for potential mechanisms that may contribute to age-dependent impaired cerebral hemodynamics following brain injury.

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The image is reconstructed with the following steps: first, the attenuated projection data acquired over 180 degrees are extended to 360 degrees and the value for the uniform attenuator is changed to a negative value. Source reconstruction analysis was performed to determine the brain regions that showed significant group difference. Chromosome instability contributes to loss of heterozygosity in mice lacking p53. Methods include the two-hybrid assay, the GST pull-down assay, and the coimmunoprecipitation (co-IP) assay. In addition, a relatively large number of susceptibility genes could be involved.

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Elderly patients who sustain penetrating trauma have more comorbidities than their younger counterparts. The bimetallic catalyst exhibited a superior activity and anti-coking performance compared to Ni/Al2O3, while the most resistant to coking behavior was Co/Al2O3. Mucoepidermoid carcinoma of salivary glands in children and adolescents: assessment of proliferation markers.

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Unlike animals, plant zygotes are transcriptionally active, implying that plants have evolved specific mechanisms to control transcriptional activation of patterning genes in the zygote. Nepal Demographic and Health Survey (NDHS) data sets 2011 were analysed. ASC14 appeared as the most efficient drug in destabilize the membrane structure of nano- and micro-size phospholipid liposomes inducing vesicle content leakage and shape elongation on giant unilamellar vesicles. Complex additives containing starch were superior to any additive by itself. To present a review of literature and to analyse a clinical retrospective series of patients with granulosa cell tumor.

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Histopathological evidence of acute or chronic ischemia was found in the majority of patients, with acute ischemia more common among those who sustained sudden death events. Clinical manifestations of hepatic arteritis in systemic lupus erythematosus.

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Methods have been developed to estimate changes in the entropy of the backbone and side chains, and for the loss of translational entropy. The endosperm cap weakened substantially in both water and ABA during the first 38 h of imbibition. Mice treated with mPhl p 5 bone marrow did not develop Phl p 5-specific IgE (or other isotypes) despite repeated administration of the allergen, while mounting and maintaining a strong humoral response towards the control allergen. Closed pleural biopsy and fluid cytology in the diagnosis of suspected pulmonary cancer with pleural involvement. Diagnosis is complex: underlying organic illness, somatization, and growing pains are all possibilities.

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Two different timings of intrauterine insemination for non-male infertility. The trial lasted 86 weeks and study treatments were delivered in the first 36 weeks, with 52 weeks of follow-up. Determination of amygdalin and its major metabolite prunasin in plasma and urine by high pressure liquid chromatography. The present and future role of continuous ambulatory peritoneal dialysis (CAPD). Layer-by-layer (LBL) technique was used in this study to explore a nanosized drug delivery system for local anesthetic therapy.

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Designs and results of a longitudinal study on periodontal health. Olfactory neuroblastoma: a histopathological ultrastructural and immunohistochemical study of 11 cases Liver transplant (LT) recipients are at significant risk for the development of neurological complications, such as altered mental status and seizures, in the postoperative period. N-acetyl-glucosamine (a midgut-lectin inhibitor) increased infection rates in some, but not all, blood manipulations.

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Latent murine gamma-herpesvirus infection is established in activated B cells, dendritic cells, and macrophages. For 50/50 mixtures (of n and i) the selectivity for nbutane was 48 and its flux was 3.8 mmol m(-2)s(-1). This paper presents four video compilations that illustrate the rich phenomenology of embouchure dystonia, in order to enhance recognition and diagnosis.

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A database was created by using the trauma registry for all nonburned, injured patients from July of 1993 through October of 1998 at our Level I trauma center. Parathyroid adenomas discovered fortuitously grow very slowly and their cell birth rate greatly declines, features explicable by an initial increase in secretory set-point.

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Pp-FAD3 is the first known yeast omega(3)-fatty acid desaturase to act on long-chain n-6 fatty acid substrates. In light of the recent understanding of oxidized sulfide metabolite formation and reactivity, comparatively few studies have been reported comparing cellular biological and in vivo effects of H2S donors versus polysulfide and persulfide donors. This review discusses one of the most commonly used of these biophysical monitors - namely saccadic eye movements. In the past few years, genetic fate mapping experiments have changed our vision of cerebellar development, particularly in redefining the origin of gabaergic and glutamatergic neurons of the cerebellar cortex and highlighting the precise spatio-temporal sequence of their generation.

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(3) Can actual antioxidant content be estimated from calculated antioxidant indices by accounting for ester content (from absorbed species) near the articular and nonarticular surfaces? Neuroborreliosis, an infection of the nervous system caused by spirochetes of the genus Borrelia, has achieved worldwide attention in the last decade as part of the clinical spectrum of Lyme disease. Volumetric measurements for the cerebrum, anterior frontal region, lateral ventricles, corpus callosum, caudate, putamen, globus pallidus, and midsagittal thalamic area were obtained.

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Quetiapine Associated Thrombotic Thrombocytopenic Purpura: A Case Report and Literature Review. The radiation dose to the reconstructed mandible ranged from 45 to 75 Gy (median 63 Gy).

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Symptom severity was assessed using the self-administered IPSS questionnaire. We want to stress the unusual presentation of this pancreatic tumor affecting the head of the gland in a male patient as well as its coexistence with a hairy cell leukemia. The evaluation of quality of life (QOL) has been used widely in cancer research, and the research of QOL for cancer patients makes more and more effect on the improvement of cancer treatment.

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RT x Set Size functions had slopes near 0 ms per item (Experiment 2). PRP was extracted from whole blood by using the double-spin technique.

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Renal fibrosis can be induced in different renal diseases, but ultimately progresses to end stage renal disease. T-cell lines chronically infected with laboratory adapted, T-cell tropic HIV-1 strains (RF, LAI, CBL-4, and NY5) induced syncytia after cocultivation with primary macrophages. There were no significant differences in the preoperative characteristics between the two groups.

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Computational model of intracellular pharmacokinetics of paclitaxel. Hyperbaric oxygen reduces infarct volume in rats by increasing oxygen supply to the ischemic periphery. Rubupungenosides A and B, two novel triterpenoid saponin dimers from the aerial parts of Rubus pungens. In the past decade there has been a change in the paradigm towards our understanding of the cellular biology of this disease process. On Friday, Aug 13, 1993, the Virginia Heart Center at Fairfax Hospital, Falls Church, implanted donor hearts in three adult recipients in a single day.

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Eighteen known miRNAs in roots and 12 known miRNAs in leaves were screened as drought-responsive miRNAs. CHIKV is responsible for induction of chikungunya fever (CF) and severe joint stiffness with the capability of developing into bilateral and systemic arthralgia or even encephalitis. Paraxis transcripts are located in the Pax3-expressing myoblasts migrating from the somites and persist in proliferating myoblasts in the limb bud. In this work, an outer-to-inner strategy is demonstrated to simultaneously fabricate core-shell NPs and assemble them onto a scaffold.

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Ligand stimulation of CD95 induces activation of Plk3 followed by phosphorylation of caspase-8. Selection of antimicrobial therapy is a critical step in DFI and should aim at overcoming biofilm disease in order to optimize the outcomes of this complex pathology. Systematic review of studies on the socioeconomic status of men who batter their intimate partners Both the isoenzymes rapidly degraded retinoic acid in the presence of linoleic acid, but lipoxygenase-2 had more cooxidation activity than lipoxygenase-3. The results suggest that bone adapts by varying the relative amount of cortical bone within the diaphysis and by varying matrix composition.

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Trafficking of non-GPI-linked cargo proteins was barely affected by p23 knockdown. Anorectal function and quality of life were assessed at enrollment and 1 year postoperatively with the Fecal Incontinence Severity Index, Fecal Incontinence Quality of Life scale, and Functional Assessment of Cancer Therapy-Colorectal Questionnaire.

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Apocalypse terminable and interminable: operation outreach for Vietnam veterans. The second device IPC-2 (Vena-Assist(R), ACI Medical) has a foot, ankle and calf cuff, applies a pressure of 80 mmHg, has a pressure rise time of 0.3 s, maintains inflation for 5.5 s, and has a cycling time of 1 min. The study was based on 3508 men and 3388 women (aged 45 to 74 years) who participated in one of the 3 MONICA (Monitoring trends and determinants on cardiovascular diseases) Augsburg surveys between 1984 and 1995, who were free of MI and angina pectoris at baseline and were followed up until 2002.

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These compounds may be present in the diet of wild birds during dry years or at the end of the growing season during normal years. There are a number of commercially available dRVVT test systems. Surgery with genioglossus advancement is indicated in hypopharynx obstruction.

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In this paper, five cholesteryl derivatives of antiviral nucleoside analogues were synthesized, involving antiviral acyclovir, didanosine and zidovudine, and the different acyl linkers, succinyl, adipoyl and phosphoryl. Physical contact between individuals in any particular group is thus common. We measured tremor frequency and amplitude during trials of postural holding and voluntary reaching between two targets at 10 different stimulation frequency settings between 0 and 185 Hz.

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Evaluation of the binding between potential anti-HIV DNA-based drugs and viral envelope glycoprotein gp120 by capillary electrophoresis with laser-induced fluorescence detection. Firefly luminescence in the study of energy transfer mechanisms. Ascertaining the course of the radial artery pre- and intraoperatively and careful dissection of the artery are essential to minimise problems of flap transfer.

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Activating receptors are associated with immunoreceptor tyrosine-based activation motif (ITAM)-bearing proteins, such as KARAP/DAP-12 and FcRgamma. At baseline, no intracardiac vs peripheral differences were noted in sP sel levels, while CD40L levels were elevated in the aorta compared to the coronary sinus and femoral venous.

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Its behavior was compared to the ether counterpart, tetraethylene glycol decanoyl ether (C10E4), whose phase diagram is well-described. TP expression is correlated with microvessel count, invasion and poor prognosis in many solid tumors. Complex regional pain syndrome: the need for multidisciplinary approach Recent studies suggest that although malocclusion may have a role, it is a small one. Perinatal HIV infection predicted higher distress and depressive symptoms, while HIV-affected status (infection/exposure) predicted low self-esteem and diminished positive outlook in the long term.

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Initial experiences with 123-Iodine-IBZM neuroreceptor scintigraphy in extrapyramidal disorders Local Intraluminal Irrigation With Argatroban During Free Flap Repair in a Patient With Heparin-Induced Thrombocytopenia.